Researchers are trying to target a specific protein-coupled receptor which is associated with two downstream pathways: t

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Researchers Are Trying To Target A Specific Protein Coupled Receptor Which Is Associated With Two Downstream Pathways T 1 (36.9 KiB) Viewed 42 times

Researchers are trying to target a specific protein-coupled receptor which is associated with two downstream pathways: the G protein pathway and the B-arrestin pathway. For this receptor, when comparing a balanced agonist to an agonist that is biased towards the protein pathway, which of the following is true? The biased agonist will have a higher affinity for the receptor in question when compared to a balanced agonist for the same receptor The biased agonist will have a quicker onset of action compared to a balanced agonist acting at the same receptor A balanced agonist will activate both pathways from the receptor in question whereas the biased agonist will activate only one specifc pathway When the G protein pathway is associated with adverse effects the biased agonist will avoid that pathway at the receptor in question and therefore avoid these adverse effects