b) Consider the following experimental results: • Total hydrolysis of a nonapeptide gave: Ala, Arg, Glu, Leu,Lys, Met, P

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B Consider The Following Experimental Results Total Hydrolysis Of A Nonapeptide Gave Ala Arg Glu Leu Lys Met P 1 (35.82 KiB) Viewed 23 times

b) Consider the following experimental results: • Total hydrolysis of a nonapeptide gave: Ala, Arg, Glu, Leu,Lys, Met, Phe, Tyr, Val • One fragment from CNBr treatment was: Tyr-Leu-Lys • One fragment from Chymotrypsin treatment was Arg-Glu-Met-Tyr • One fragment from Trypsin treatment was Val-Ala-Phe-Arg i. Deduce, with suitable explanations, the amino acid sequence of the nonapeptide. ii. The reagent shown below is widely utilized in the sequencing of peptides. Treatment of the nonapeptide you deduced in part i. with this reagent yields a phenylthiohydantoin derivative, compound 1, and an octapeptide. Write a mechanism for the formation of compound 1. O N=CES