Section 7.2.1 said that a typical globular protein is a sphere of radius 10nm. Cells have a high concentration of such p

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Section 7 2 1 Said That A Typical Globular Protein Is A Sphere Of Radius 10nm Cells Have A High Concentration Of Such P 1 (484.34 KiB) Viewed 41 times

Section 7.2.1 said that a typical globular protein is a sphere of radius 10nm. Cells have a high concentration of such proteins; for illustration suppose that they occupy about 30% of the interior volume. A) Imagine two large, flat objects inside the cell (representing two big macromolecular complexes with complementary surfaces). When they approach each other closer than a certain separation, they'll feel an effective depletion force driving them still closer, caused by the surrounding suspension of smaller proteins. Draw a picture, assuming the surfaces are parallel as they approach each other. Estimate the separation at which the force begins. B) If the contact area is 10 m2, estimate the total free energy reduction when the surfaces stick. You may neglect any other possible interactions between the surfaces, and as always assume that we can still use the van 't Hoff (dilute. suspension) formula for osmotic pressure. Is it significant compared to kBT,?