4. A patient with gastric pain was prescribed an analgesic (400mg oral tablet) and was instructed to take it once every

[answerhappygod]

4.
A patient with gastric pain was prescribed an analgesic (400mg oral tablet) and was instructed to
take it once every 12 hours (twice a day). The bioavailability of the analgesic is known to be 48%.
(25 marks)
a. Discuss the bioavailability of the administered analgesic and the factors that can affect its
bioavailability (7 marks)
b. Where will the greater absorption of the orally administered analgesic occur? Give a reason for
your answer (3 marks)
c. Reflecting on the pharmacokinetic principles, explain why the analgesic is administered twice daily.
(6 marks)
d. Explain the possible pharmacokinetic processes which orally administered analgesics will follow
after absorption (6 marks)
e. How will the analgesic be excreted from the body? Describe at least two routes of elimination (3
marks)
please words should be 400 and some refrences please