- May You Please Answer All The Questions Below 1 (30.74 KiB) Viewed 33 times
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A candidate drug is generated by which of the following? a. Target validation b. Therapeutic concept c. Lead optimization d. Target selection e. Lead finding
Which of the following comprise the majority of drug targets? Proteins Organelles Viruses Bacteria Organs QUESTION 18 Which of the following answers explains why phase III trials are multicentre? a. to reduce costs b. to account for genetic polymorphisms c. to account for regional differences in diet d. a and c e. b and c
In which of the following conditions might it be therapeutically useful to enhance cholinergic neurotransmission (at tissue target level)? Tick ALL that apply. This question has negative marking but the lowest possible mark for it is 0 . a. Anticholinesterase poisoning b. Constipation c. Excessive sweating d. Gastric ulcer e. Glaucoma f. Incontinence g. Tachycardia h. Myasthenia gravis
"Open-label" refers to which one of the following; a. Allowing patients to know which treatment they're taking b. Mixing up the labels so that patients don't know which substance they're taking c. Showing the clinicians which drug is active and which is a placebo d. Using only non-patented medicines as controls e. All of the above QUESTION 21 Which one of the following describes the LD50 ? a. The mean effective dose b. The dose that is fatal to half the subjects c. The median dose that has adverse effects d. The maximum safe dose e. The minimum lethal dose
Some of these statements about structure-based drug design are correct. Tick ALL that are correct. This question has negative marking but the lowest possible mark for it is 0. a. It requires no structural knowledge of the target, and relies on knowledge about the ligand. b. Structure-based drug design uses knowledge of the structure of the target to find ligands that bind to it. c. It usually involves using X-ray crystallography. d. It usually involves Nuclear Magnetic Resonance. e. Optimization of the interactions between ligand and target usually requires an increase in the number of polar Cl−groups in the ligand. f. Optimization of the interactions between ligand and target usually requires a decrease in the number of CH3 groups in the target.
Which answer best describes the main purpose of Phase IV testing? a. Determine immediate adverse effects b. Determine variation in absorption c. Determine unreported toxicity d. Determine therapeutic window e. Determine tolerability
Complete the sentence below by selecting the appropriate words from the list below. The sympathetic nervous system nasal mucus production through acting at receptors. Stimulates Inhibits Acetylcholine Noradrenaline Muscle nicotinic CNS nicotinic Ganglion nicotinic M1 M2 M3 Alpha Beta-1 Beta-2 Beta-3
Phase I trials typically take how long? a. 2−3 years b. 2−5 years c. 2-3 weeks d. 6 months e. 12 weeks