A biological marker (or biomarker) is a substance that canindicate a change in physiological state. The specificity of abiomarker can vary from general indications of poor health tospecific diagnosis of disease.
Creatine kinase (CK) is a serum enzyme of clinical significance.Measurement of total CK is a general indicator of tissue damage.Elevated total CK can be observed in:
Further studies revealed that there are three different forms,or isoenzymes, of CK. These forms have been correlated to aparticular tissue type, thus increasing the specificity of CK as abiomarker!
CK-MM: skeletal muscle
CK-MB: heart
CK-BB: brain
A physician ordered a CK isoenzyme profile for two patients.Below is an image of the results:
Figure 1. Image of CK isoenzyme profile results. M: markers(control ladder), P1/P2: patients, N: normal control.
Discussion questions:
A biological marker (or biomarker) is a substance that can indicate a change in physiological state. The specificity of
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A biological marker (or biomarker) is a substance that can indicate a change in physiological state. The specificity of
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