Which of the following statements about the double negative (DN) population of developing thymocytes are true? Turned on

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Which of the following statements about the double negative (DN) population of developing thymocytes are true? Turned on expression of RAG1/2 to form a rearranged TCRbeta chain via V/D/J recombination. O Subjected to beta selection as the first checkpoint in thymocyte maturation. O Express the surrogate alpha chain (pTalpha) which pairs with a TCRbeta chain to form the preTCR. Located in the cortex of the thymus. O All of these statements are true.

An important source of combinatorial diversity in lymphocyte antigen receptors is the splicing together of various V.D, and J gene segments. Which of these enzymes plays a key role in mediating combinatorial diversity during these rearrangements? RAG1/2 PKC-theta Granzyme B OLck

Which of the following signaling events is NOT engaged downstream of phospholipase C (PLC)-gamma activation? Heterodimerization of the subunits c-Fos and c-Jun to form the transcription factor AP-1 O IkappaB degradation and resulting translocation of NFkappaB into the nucleus PIP3 generation at the plasma membrane which recruits and activates Akt, leading to cytoskeletal remodeling O Recruitment of protein kinase C (PKC)-theta to the plasma membrane O Calcium ion (Ca2+) release from the endoplasmic reticulum (ER)