CFTR is a protein with 12 transmembrane domains that is mutated in many cystic fibrosis patients. Its molecular analysis

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Cftr Is A Protein With 12 Transmembrane Domains That Is Mutated In Many Cystic Fibrosis Patients Its Molecular Analysis 1 (47.05 KiB) Viewed 79 times

CFTR is a protein with 12 transmembrane domains that is mutated in many cystic fibrosis patients. Its molecular analysis led to some surprises. CFTR is homologous to ABC transporters, which use ATP hydrolysis to pump solutes in or out of the cell, but it shows an unusual behavior. Which of the following statements would suggest that CFTR functions differently from the ABC transporter family? A: CFTR binds to Cl to move the ions across membranes B: CFTR can move Cl against a concentration gradient C: CFTR produces a robust Cl current across membranes D: CFTR requires ATP to move Cl- across membranes