- Answer Questions 13 Through 16 Using The Data Presented Below In Fig 3 And Based On The Information In The Table 1 (74.6 KiB) Viewed 64 times
- Answer Questions 13 Through 16 Using The Data Presented Below In Fig 3 And Based On The Information In The Table 2 (97.34 KiB) Viewed 64 times
+ Answer questions #13 through # 16 using the data presented below in Fig. 3, and based on the information in the Table 1 below and in your text. Note: A = adrenaline; NA= noradrenaline. Explain your answers. Table 1. Adrenoceptors Alpha 1-adrenoceptors Nomenclature Other names Potency order Selective agonists Selective antagonists Alpha 2-adrenoceptors Nomenclature Other names Potency order Selective agonists Selective antagonists Coupling Beta 1-adrenoceptors Nomenclature Other names Potency order Selective agonists Selective antagonists alpha 1A alpha 1a, alpha 1c A61603 NA>adrenalin adrenaline NA KMD3213 alpha 2A BRL44408 GV alpha 18 beta 1 alpha 1b alpha 2D adrenaline>N adrenaline>NA oxymetazolin NA=adrenalin Noradrenalin betatoxol AH11110A alpha 28 prazosin G% beta 2 adrenaline>NA procaterol ICI118551 alpha 1D alpha 1A/D adrenaline=NA BMY7378 alpha 2C Adrenaline>NA prazosin GV beta 3 atypical NA=adrenaline BRL37344 SR59230A beta 4 NA>adrenaline bupranolol
Coupling A. Contraction of arterial strips Relaxation of bronchial smooth muscle Contraction of heart A Goo ΝΑ A Goo B. Slide 1, ΝΑ Gs or Gu NA NA NA+ propanolol I+ phenolamine NA+ phenolamine G A NA ryu Log concentration of catecholamine Log concentration of catecholamine NA+ phenolamine I+ propanolol 14. (2.5pts) Which receptor subtype(s) mediate(s) contraction of heart? Why? Answer based on the data presented above. (Figure 3 and the Table 1). Explain your answer. NA+ propanolol Figure 3. A. Dose-response curves (arbitrary scales) show relative potencies of three catecholamines on experimental muscle preparations. Changes in forces of contraction or relaxation are shown for each muscle tissue hung in separate tissue baths after addition of increasing concentrations of each catecholamine. B. Change in force of contraction or relaxation (arbitrary scale) of different tissues hung in separate tissue baths after addition of increasing concentrations of catecholamine in absence and presence of a fixed concentration of phentolamine or propanolol NA, noradrenaline; A, adrenaline; I, isoproterenol. 13. (2.5pts) Which receptor subtype(s) mediate(s) contraction of arterial strips? Why? Answer based on the data presented above. (Figure 3 and the Table 1). Explain your answer. 15. (2.5pts) Which receptor subtype(s) mediate(s) relaxation f bronchial smooth muscle? Why? Answer based on the data presented above. (Figure 3 and the Table 1). Explain your answer.