As a virologist in a diagnostic laboratory in south-east Queensland your are currently investigating a mysterious febril

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As a virologist in a diagnostic laboratory in south-eastQueensland your are currently investigating a mysterious febriledisease with rash in 10 patents whose serum samples have been sentto your lab for routine diagnostics. While the samples werenegative for all viral infections( exotic and endemic to Australia)known to be associated with those symptoms, from one of the samplesyou managed to isolate a vrius by culturing theserum on both humanand tick cells. Deep sequencing of the viral genome revealed it tobe a new(not previously reported) negative-strand RNA virus withgenetic similarity to a new group of viruses isolated fromticks.Some of the patients also reported a history of tick biteswhile bush walking in the weeks prior to the disease onset. Basedon a hypothesis that this is an acute disease transmitted byticks:
Describe the design of an epidemiological investigationto establish that the new virus you have isolated is the causativeagent of the disease in these 10 patients. In youranswer:
A.Describe the design of both retrospective and cohort studiesand TWO(2) main diagostic techniques you would use(6 mars)
B.Explain how your study design would contribute to fulfillingKoch’s postulates(2marks)
C. Briefly describe an additional epidemiological study thatcould be undertaken to provide supporting evidence of yourhypothesis of tick-borne transmission.(2 marks)