Which of the following is correct regarding development of tolerance to morphine? A. Tolerance to different opioid effec

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Which of the following is correct regarding development of
tolerance to morphine?
A. Tolerance to different opioid effects occurs at
approximately the same rate and to the same degree.
B. Tolerance development often involves desensitization of
opioid receptors and decreased number of receptors.
C. With repeated use, opioid receptors are overexpressed on the
cell surface in order to compensate for the presence of
morphine.
D. Intracellular c-AMP and Ca++ levels are decreased in
tolerance development to morphine.
E. Tolerance production is most likely when the morphine is
administered intermittently.