Consider the modified anti-tumor intermediate below and answer the following: 6 ОАс OH HO HO d OTBS K O. CHO f НО Ph NO₂

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Consider the modified anti-tumor intermediate below and answer the following: 6 ОАс OH HO HO d OTBS K O. CHO f НО Ph NO₂ How many acyl groups are in the molecule above? 4 (enter number only) True or False. The formyl group generated at (f) could be accomplished from the oxidation of an alcohol with MnO₂ (Tor F only) T How many free carboxylate groups are formed after treatment with complete base hydrolysis conditions conditions? (Number only) Considering only the diasterotopic Hs, which letter indicates the position of the proton that is the most downfield in the ¹H (enter letter only) NMR? Considering only the methine Hs, which letter indicates the position of the proton that is the most downfield in the ¹H NMR? (enter letter only) Which letter indicates the position of the proton signal that is the most upfield in the ¹H NMR? e
During the process of alpha halogenation of acetophenone in the presence of FeBrg, which statement best describes the most favorable reactive intermediate after step # 1? Choose all that apply. cationic acyl oxygen is formed Danionic acyl oxygenis formed IR signal between 1680-1850 cm1 no IR signal between 1680-1850 cm¹¹ enol is formed alpha halogenation does not occur EAS is preferred t Fe carries a postive charge Fe carries an negative charge Fe remains neutral T
Consider the reaction proposal below and answer the following (Do not consider alpha halogenation). phenol a) 1) 2.0 eq EtCOCL FeCl; b) 1) Acy0, pyr 2) Br 2) Br 3) HCl(aq), heat 3) HCl(aq), heat 4) ECOCL pyridine 1) ACCL pyr 2) Br 3) ECOCL pyr 4) NaOH(aq), beat 5) HCl(aq) to neutralize C OH Br d) No synthesis presented would be effective e) Substitution Pattern Not possible with Phenol, Starting Material a. Which option(s) can generate the target molecule as the major product? a and c b. True or False. The target molecule would have a lower pKa value than the phenol. [Select] c. Using the letters assigned on the molecule which Ar-H signal would be the most deshielded in the ¹H NMR spectrum? C d. Using the letters assigned on the molecule which Ar-H signal would be the most shielded in the ¹H NMR spectrum? b e. Consider the target molecule and describe the splitting pattern of the alpha carbon in the ¹H NMR. doublet