| The questions below all refer to the following pedigree. In humans, the HFE locus (H/h) is crucial for the regulation

[answerhappygod]

The Questions Below All Refer To The Following Pedigree In Humans The Hfe Locus H H Is Crucial For The Regulation 1 (95.35 KiB) Viewed 35 times

| The questions below all refer to the following pedigree. In humans, the HFE locus (H/h) is crucial for the regulation of iron absorption into the body. Mutations at this allele result in the accumulation of dangerously high levels of iron within the body. This can cause a wide variety of problems, including (but not limited to) skin discoloration, arthritis, heart failure, and liver failure. In the pedigree below, black circles/squares represent individuals affected by the disorder. White circles/squares represent unaffected individuals. Carriers are not identified for you (you must deduce based on the information provided). Remember, if a trait is rare in a population (such as this one), we assume individuals marrying into the family are NOT carriers unless the information provided indicates that they must be. I || ||| IV B1. C1_ B2 C2 A1 B3 C3 A2 B4 B5 OH C4 D4 C5 D1_ D2_ 1) It is extremely helpful to find all the genotypes for each individual within the pedigree. Circle/highlight the following individuals' genotypes from the pedigree (0.25 pts for each correct answer): a. A1HH or Hh or bh b. B4: HH or Ha or bh c. C3HH or Hh or bh B6, D5. d. D2: HH or Hh or bh 2) What is the probability that D1 is a carrier of this disorder? Show your work with a Punnett Square in addition to stating the probability. (1 points total, 0.5 pts for work and 0.5pts for correct answer). 3) Individuals B5 and B6 are considering having additional children. However, having already had a child with this disorder, they visit a genetic counselor to determine what the probability is that their future child would have the disorder. If B5 and B6 have another child, what is the probability that the child will have the disorder? Show your work with a Punnett Square, in addition to stating the probability. (1 points total, 0.5 pts for work and 0.5pts for correct answer). 4) D5 goes on an exotic vacation and meets the love of their life, George. It is determined that 5% of the population where George lives is a carrier for this disorder. If we assume George has the same risk of being a carrier as everyone else in their population (5%), what is the probability that D5 and George will have a child with the disorder? Show your work (via math and/or Punnett squares, 1 points) in addition to stating the final probability (1 points). Hint: You will need to determine all of the following information in order to calculate the final answer. Probability that D5 is a carrier: Probability that George is a Carrier:_________ Probability that two carriers will have an affected child: Final Probability that D5 and George would have an affected child: