For the following patient, identify the lesion site [Basal ganglia, cerebellum, association cortex, upper motor neurons

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For the following patient, identify
the lesion site [Basal ganglia, cerebellum,
association cortex, upper motor neurons (UMNs; motor cortex or
internal capsule), lower motor neurons (LMNs; final common
pathway), peripheral nerve (axons of LMNs), neuromuscular junction
(NMJ), muscle] and a possible diagnosis.
Be careful not to confuse a description with a
diagnosis. For example: “spastic paralysis” is
not a diagnosis. It is a description of what happens following UMN
damage. The CAUSE of that damage would be the actual diagnosis.
6. A 45-year-old female presents with a six-month history of
increasing generalized weakness. She finds it difficult to grasp a
jar and unscrew the lid. She has difficulty placing objects on the
shelf above her head. She finds that she has to pull herself up by
her arms to arise from a chair. Her speech become "slurred" and she
finds that occasionally she will choke while drinking a class of
water. On examination there is marked weakness in all her
extremities. There is significant wasting of muscles in her upper
and lower extremities and fasciculations are noted. Tapping the
muscle tendons fails to elicit muscle contraction. Muscle tone is
normal. There are no involuntary movements except for the
fasciculations.