1. Draw the starting material’s structure and provide intermediates after the first and second C-C bond formation steps in order to describe the reaction mechanism. Which imidazole substitution pattern would you expect if a reagent with a substituent at the methylene position would have been used?
1 Draw The Starting Material S Structure And Provide Intermediates After The First And Second C C Bond Formation Steps 1 (52.92 KiB) Viewed 7 times
1 Draw The Starting Material S Structure And Provide Intermediates After The First And Second C C Bond Formation Steps 2 (52.92 KiB) Viewed 7 times
1. The following reaction successfully installed an imidazole. Draw the starting material's structure and provide intermediates after the first and second C-C bond formation steps in order to describe the reaction mechanism. Which imidazole substitution pattern would you expect if a reagent with a substituent at the methylene position would have been used? 2. Reactions with free hydrazoic acid are highly unfavored in the laboratory due to safety concerns. This stimulated the search for alternative reagents and diphenylphosphoryl azide (DPPA) is one that is often used. In the following example, the reagent serves as a dehydration agent as well as a source of azide. Fill in the missing intermediate and the product. HN PhO-P Pho Ts NC base DPPA pyridine reflux
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