Figure 1. Structure of (2E)-3-[4,5-bis(2,3-dihydro-1,4-benzodioxin-6-yl )furan-2-yl)prop-2-enoic acid, known as 10B-10.

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Figure 1 Structure Of 2e 3 4 5 Bis 2 3 Dihydro 1 4 Benzodioxin 6 Yl Furan 2 Yl Prop 2 Enoic Acid Known As 10b 10 1 (81.97 KiB) Viewed 8 times

Figure 1 Structure Of 2e 3 4 5 Bis 2 3 Dihydro 1 4 Benzodioxin 6 Yl Furan 2 Yl Prop 2 Enoic Acid Known As 10b 10 2 (75.61 KiB) Viewed 8 times

Figure 1. Structure of (2E)-3-[4,5-bis(2,3-dihydro-1,4-benzodioxin-6-yl )furan-2-yl)prop-2-enoic acid, known as 10B-10. 10B-10 has a MW-406.390 g/mol. The terminal carboxyl group is predicted to have a pK, of 3.34 (predicted by MarvinSketch). However, I need to measure this pK, experimentally to be validate this number. So, here is where you all come into the project. I want to use the predicted number to simulate the titration curve to design the proper experiment to get a good data set from which I can accurately determine the pK, for this carboxyl group. My initial design is as follows: Start with 10 mL of 10 mM 10B-10 in the beaker. In the burette I will use 10 mM NaOH. Please calculate and plot the pH values (in Excel) that you calculate to the right of the listed total volume of 10 mM NaOH that was added. In the plot, the pH is on the y-axis. Show all of your work (you can take a picture of your work and insert into this document) and insert your Excel plot into this Word document. Convert your completed work to a PDF file (use Word to convert your *.docx file to a *.pdf file) via Canvas and use the file title: LastName_FirstName_extra_credit.pdf mL 10 mM NaOH introduced per addition 0 1 1 2 44 My research needs your help. The molecule 10B-10 (Figure 1) has the potential to be a drug and could be used to offset the potentially life-threatening chronic cardiotoxicity associated with the use of anthracycline chemotherapy agents often used to treat a variety of cancers. 8 Total mL 10 mM NaOH added 0 1 2 4 8 16 Calculated pH
OH Figure 1. Structure of (2E)-3-[4,5-bis(2,3-dihydro-1,4-benzodioxin-6-yl )furan-2-yl]prop-2-enoic acid, known as 10B-10. 10B-10 has a MW = 406.390 g/mol.