A 28-year-old-woman of Eastern European Jewish decent comes to the office 2 days after she noticed a lump in her left br

[answerhappygod]

A 28-year-old-woman of Eastern European Jewish decent comes to the office 2 days after she noticed a lump in her left breast. Her maternal aunt and mother were diagnose with ovarian cancer at the age of 54 years and died at the age of 60 years; her maternal aunt and mother were diagnosed with breast cancer at the ages of 36 and 40 years, respectively. The aunt died as a result of the disease at the age of 50 years. The patient is concerned that she may have inherited a genetic mutation that would predispose her to breast and/or ovarian cancer. Genetic testing of this patient and her mother are most likely to show a germline mutation in a component of which of the following pathways?


A. DNA mismatch repair
B. DNA polymerase proofreading
C. DNA base excision repair
D. DNA nucleotide excision repair
E. Recombinational double-stranded DNA break repair