A male newborn is found to have a decreased blood thyroxine (T,J concentration on newborn screening. Physical examinatio

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A male newborn is found to have a decreased blood thyroxine (T,J concentration on newborn screening. Physical examinatio

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A male newborn is found to have a decreased blood thyroxine (T,J concentration on newborn screening. Physical examination shows no abnormalities. Serum studies show decreased concentrations of triiodothyronine (T:Jand T4. His serum free T4 and thyroid-stimulating hormone (TSH) concentrations are within the reference ranges. Which of the following best explains these findings?


A. Maternal antithyroid antibodies
B. Organification defect in T3 and T4 synthesis
C. Thyroid dysgenesis
D. Thyroid hormone-binding globulin deficiency TSH deficiency
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