Two essential parameters that determine the efficiency of cell capture on the CTC chip are (1) flow velocity because it

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Two essential parameters that determine the efficiency of cellcapture on the CTC chip are (1) flow velocity because it influencesthe duration of cell–micro post-contact; and (2) shear force, whichmust be sufficiently low to ensure maximum cell–micro postattachment [1]. How can we improve the efficiency of this kindof chip?
[1] Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D,Ulkus L, Smith MR, Kwak EL, Digumarthy S, Muzikansky A, Ryan P.Isolation of rare circulating tumour cells in cancer patients bymicrochip technology. Nature. 2007 Dec;450(7173):1235-9.