Senescence Associated Secretory Phenotype shortening of telomeres which results in an aneuploid karyotype cells trigger

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Senescence Associated Secretory Phenotype
shortening of telomeres which results in an aneuploidkaryotype
cells trigger caspase cascades which recycle cell components
cells secrete pro-inflammatory signals which recruit immunecells and may promote tumorigenesis
successive rounds of chromosome breakage and fusion result inaneuploidy
caused by DNA polymerase not being able to attach the ends ofchromosomes