You mutate a heterotrimeric G protein so that the alpha subunit can no longer dissociate from the beta and gamma subunit
Posted: Tue Jul 05, 2022 7:42 am
You mutate a heterotrimeric G protein so that the alpha subunit can no longer dissociate from the beta and gamma subunits. How would this mutation affect G protein-coupled receptor (GPCR) signaling? The signal transduction pathway would activate normally, but be unable to terminate properly. O Cyclic AMP levels would rise uncontrollably. O Adenylyl cyclase would remain activated. The signal transduction pathway could not activate in response to ligand binding. The ligand would not bind to the GPCR. Submit Request Answer