2. Assume that the gene for pyruvate dehydrogenase kinase is mutated and the mutated enzyme remain active in the presenc
Posted: Thu Jun 30, 2022 6:11 pm
2. Assume that the gene for pyruvate dehydrogenase kinase is mutated and the mutated enzyme remain active in the presence or absence of upstream regulatory signals. Patients with such a gene mutation exhibit all the symptoms of beriberi. Do you think beriberi, resulting from such mutations of pyruvate dehydrogenase kinase, can be successfully treated by placing such patients on a thiamine-enriched diet? Briefly explain your reasonings.