2. Assume that the gene for pyruvate dehydrogenase kinase is mutated and the mutated enzyme remain active in the presenc

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2 Assume That The Gene For Pyruvate Dehydrogenase Kinase Is Mutated And The Mutated Enzyme Remain Active In The Presenc 1 (58.4 KiB) Viewed 54 times

2. Assume that the gene for pyruvate dehydrogenase kinase is mutated and the mutated enzyme remain active in the presence or absence of upstream regulatory signals. Patients with such a gene mutation exhibit all the symptoms of beriberi. Do you think beriberi, resulting from such mutations of pyruvate dehydrogenase kinase, can be successfully treated by placing such patients on a thiamine-enriched diet? Briefly explain your reasonings.