Discuss the normal physiological function of the kidney and the ramifications of a non-functioning kidney on a systemic

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Discuss the normal physiological function of the kidney and the
ramifications of a non-functioning kidney on a systemic level. Loss
of kidney function impacts all of the systems in our body, explain
the physiology and pathophysiology of
the many manifestations of chronic kidney failure, you will need to
go outside of your text for this information. This should be a very
detailed physiological exploration, not just a list of
manifestations. Remember to explain WHY.