Homework Question 2 Using the information provided in Question 1 above, please calculate the following PK parameters whe

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Homework Question 2
Using the information provided in Question 1 above, please calculate the following PK parameters when two 500 mg procainamide tablets are given to a 70kg patient with normal absorption and clearance functions every 6 hours:
In a 70 kg patient with renal impairment, the elimination half-life of procainamide is reported to be 14 hours, but the absorption rate is not affected. To keep the average plasma level at 6 μg/mL at the steady state, please calculate:
Procainamide is used for the treatment of ventricular tachyarhythmia. It is administered intravenously, orally and intramuscularly, and its therapeutic range is 4-8 g/ml. The toxic level is 15 pg/mL. PK studies indicate that the elimination half-life is 3 hours and the apparent volume of distribution of 2 Lkg. The oral PK studies indicate that the absorption rate constant (ka) - 2.8 hr, and the fraction of dose absorbed F-90%. Procainamide oral tablets are available in 250 and 500 mg strengths. A 75kg patient is given procainamide by either intravenously or orally, please answer the following questions: 1. Calculate the IV dose of procainamide if the initial plasma concentration is 8 ug/mL.. 2. Calculate peak plasma concentration and peak time if the patient is given one 500 mg tablet. 3. Will one 500 mg oral tablet provide peak concentration high enough to control arrhythmia? What is the minimum oral dose that would be needed to reach the minimum therapeutic level? 4. At what time point is the absorption rate the highest? At what time point is the elimination rate the highest? 5. Calculate the absorbable amount of drug remaining at the site of absorption (Xa) at a time when the rate of absorption is equal to the rate of elimination if the patient is given two 500 mg tablets. What is the rate of absorption at this point? What does this mean? 6. In a 75 kg patient with renal impairment, the elimination half-life of procainamide is reported to be 14 hours, but the absorption rate is not affected. Calculate tmax and max for the renal impaired patient following the administration of two 500 mg tablets. Is the patient still safe! Homework Question 2 Using the information provided in Question above, please calculate the following PK parameters when two 500 mg procainamide tablets are given to a 70kg patient with normal absorption and clearance functions every 6 hours 7. Peak and trough concentration at the steady state 8. Average plasma concentration at the steady state In a 70 kg patient with renal impairment, the elimination half- life of procainamide is reported to be 14 hours, but the absorption rate is not affected. To keep the average plasma level at 6 ug/ml. at the steady state, please calculate: 9. Maintenance dose 10. Loading dose