2. The compound called benzamidine, along with some of its para substituted derivatives, has been shown to bind to the a

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2 The Compound Called Benzamidine Along With Some Of Its Para Substituted Derivatives Has Been Shown To Bind To The A 1 (61.73 KiB) Viewed 85 times

2. The compound called benzamidine, along with some of its para substituted derivatives, has been shown to bind to the active site of a certain enzyme and inhibit its function. The crystal structure below shows how these inhibitors bind inside the hydrophobic pocket of the enzyme active site. (Note that red oxygen, blue = nitrogen, green - active site peptide carbons, and yellow a ligand carbons. The "X" represents the varying para substituent.) @NH₂ @NH2 NH2 NH NH ΝΗ, benzamidine HN p-aminobenzamidine HC p-methylbenzamidine Ser 190 Ser 195 Asp 189 His57 X Benzamidine Gly219 Asp 102 a) Identify the strongest possible intermolecular interactions that could occur between para-aminobenzamidine and the trypsin binding pocket, and name the specific amino acid residues in the pocket that could participate in those interactions b) Identify the strongest possible intermolecular interactions that could occur between para-methylbenzamidine and the trypsin binding pocket and name the specific amino acid residues in the pocket that could participate in these interactions. c) Based on your answers to parts (a) and (b), which of these two potential ligands would you expect to bind more tightly to this enzyme's active site?