2. Activated-protein-C (APC) resistance is a serum marker that has been associated with thrombosis (the formation of blo

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2 Activated Protein C Apc Resistance Is A Serum Marker That Has Been Associated With Thrombosis The Formation Of Blo 1 (74.36 KiB) Viewed 20 times

2. Activated-protein-C (APC) resistance is a serum marker that has been associated with thrombosis (the formation of blood clots often leading to heart attacks) among adults. A study assessed this risk factor among adolescents. To assess the reproducibility of the assay, a split-sample technique was used in which a blood sample was provided by 10 people; each sample was split into two aliquots (sub-samples), and each aliquot was assessed separately. The table below gives the results. APC resistance split-samples data Sample number A B A-B 1 2.22 1.88 0.34 2 3.42 3.59 -0.17 3 3.68 3.01 0.67 4 2.64 2.37 0.27 5 2.68 2.26 0.42 6 3.29 3.04 0.25 7 3.85 3.57 0.28 8 2.24 2.29 -0.05 9 3.25 3.39 -0.14 10 3.30 3.16 0.14 (a) To assess the variability of the assay, the investigators need to compute the coefficient of variation. Compute the coefficient of variation (CV) for each subject by obtaining the mean and standard deviation over the 2 replicates for each subject. (b) Compute the average CV over the 10 subjects as an overall measure of variability of the assay. In general, a CV of <10% is considered excellent, > 10% and <20% is considered good, and <30% is considered fair, and > 30% is considered poor, How would you characterize the reliability of the APC assay based on these criteria?