Chemists at a food additive company have developed a new
artificial sweetener that shows no signs of causing cancer or other
serious illnesses in rodents. Based on preliminary human tests,
however, it can cause drowsiness at plasma levels above 30 mg/L.
Measurements from these preliminary tests indicate the following
human toxicokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs =
0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters,
estimate the following for a 49 kg woman after she consumes 1.0 g
of the new sweetener:
(a) Estimate the plasma concentration of the sweetener at 1hr, 6
hr, and 20hr after consumption. (3points for each timepoint, 9
points total)
Chemists at a food additive company have developed a new artificial sweetener that shows no signs of causing cancer or o
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