For Drugs selectivity all below statements are right EXCEPT 1. Selective drug less likely to produce side effects in com

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For Drugs Selectivity All Below Statements Are Right Except 1 Selective Drug Less Likely To Produce Side Effects In Com 1 (121.06 KiB) Viewed 52 times

For Drugs selectivity all below statements are right EXCEPT 1. Selective drug less likely to produce side effects in compare with unselective once 2. Selectivity can be achieved through changing route of administration 3. Selectivity can be achieved through increase drug absorption 4. Selective drug usually has higher affinity to the target drug away more than the nontargeted receptors Elimination half life is 1. Essential to calculation absorption rate 2. Theoretical time that can affect drug distribution 3. The time needed to eliminate half the plasma concentration 4. Fixed when drug follow zero order kinetic while varied depending on dose when drug follow first order kinetic. Clearance 1. Has high impact on drug dissolution 2. Can determine drug elimination t1/2 3. Cause idiosyncrasy side effects 4. Does not affected by several organ failure Drug-drug interaction 1. Only important when drug has wide therapeutic window 2. Some drugs can affect gut motility lead to accelerate absorption 3. Enzymes inducers can increase or decrease drug effect 4. It always harmful and should be avoided acentors