When 100 mg of a drug was given as an IV bolus dose, the
following plasma concentration vs. time relationship ( C in
mg/L and time in h ) was observed: C =
(16)e-0.15t. Use this information for the next two question.
i) The concentration of the drug in the plasma (C) at 30
min is ______ mg/L? Round the answer to nearest
integer.
ii) If the dose is doubled to 200 mg, assuming linear
kinetics, the initial concentration of the drug in the plasma will
be _____ mg/L? Round the answer to nearest integer.
Thank you
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