The serum protein binding of azithromycin is concentration dependent, ranging from 51% at 0.02 mg/mL to 7% at 2.0 mg/mL

[answerhappygod]

The serum protein binding of azithromycin is concentration
dependent, ranging from 51% at 0.02 mg/mL to 7% at 2.0 mg/mL as
reported in the literature.
Following oral administration, azithromycin is widely
distributed throughout the body with an apparent steady-state
volume of distribution of 31.1 L/kg.
Higher azithromycin concentrations in tissues than in plasma or
serum have been observed.
•What is the apparent VD for a subject weighing 70 kg?
•Is the apparent VD greater or lower than the plasma volume of
the body for this subject?
•Do you think protein binding affect the distribution of this
drug?