(please solve those as soon as possible) 1. Two drugs, A and B, are entirely eliminated through the kidney by glomerular

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(please solve those as soon as possible)
1. Two drugs, A and B, are entirely eliminated through the kidney by glomerular filtration (120 mL/min), with no reabsorption. Drug A has half the distribution volume of drug B, and the VD of drug B is 15 L. What are the drug clearances for each drug based on the classical and physiologic approaches?
2.It was determined that 95% of an oral 80-mg dose of verapamil was absorbed in a 70 kg test subject. However, because of extensive biotransformation during its first pass through the portal circulation, the bioavailability of verapamil was only 25%. Assuming a liver blood flow of 1500 mL/min, determine the hepatic clearance of verapamil in this situation.