Neural activation of skeletal muscle involves a sequence of
steps. Understanding the steps in this sequence helps you to
determine the locus of disturbances that affect muscle
contraction.
You are given an isolated muscle with its motor nerve intact.
This preparation is arranged so that you can make
electrophysiological measurements from the nerve and muscle as well
as mechanical measurements of muscle contraction. You observe that
if caffeine is added to the fluid bathing the muscle preparation,
the peak tension developed in the muscle twitch produced by
stimulating the motor nerve is increased.
3. (1pts) What might happen to muscle contraction if
acetylcholinesterase were added to the preparation?
4. (1pt) If you were to induce muscle contractions at a level
that mimics high-intensity exercise (90% maximum), what fuel(s)
would you need to provide the muscle? How might that change if you
were to mimic 20% exercise intensity?
5. (2pts) If you accidentally add too much caffeine to the
preparation, the muscle stays contracted. Explain what is happening
and what you might expect to see after some time.
6. (2pt) A motor unit includes a neuron and all of the muscle
fibers it innervates. Explain how the innervations and measurements
of muscle tension might differ if the preparation was an eye muscle
as compared to the quadriceps. (Hint: consider motor units)
Neural activation of skeletal muscle involves a sequence of steps. Understanding the steps in this sequence helps you to
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