Patient History: A person has been referred to an oncologist with an abnormally high white blood cell count. Flow cytome

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Patient History: A person has been referred to
an oncologist with an abnormally high white blood cell count. Flow
cytometry analysis of a blood sample reveals they have very high
levels of large malignant B cells in circulation. Molecular
profiling shows that these B cells have a mutation in the p53 gene,
which is associated with a poorer patient prognosis. These
malignant B cells express the CD19 antigen, like all B cells, but
they also express gB antigen from the Epstein Barr virus, which may
be oncogenic.
Diagnosis: The patient is diagnosed with
diffuse large B cell lymphoma (DLBCL). They are initially treated
with chemotherapy, followed by a stem cell transplant from the bone
marrow tissue bank. They develop graft versus host disease (GvHD)
and are treated with immune-suppressive drugs.
Given this person’s symptoms and diagnosis, please answer the
following questions: