Scientists are investigating the genetic determinants of over-eating using a rat model. In a randomly breeding laborator

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Scientists Are Investigating The Genetic Determinants Of Over Eating Using A Rat Model In A Randomly Breeding Laborator 1 (58.43 KiB) Viewed 244 times

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Scientists are investigating the genetic determinants of over-eating using a rat model. In a randomly breeding laboratory colony. each rat will on average consume 60 g of feed per day with a variance of 20 g/day. Two inbred lines were created from this original population (after five generations of selection and inbreeding), one with a high food intake (mean consumption: 95 g/day) and one with low food intake (mean consumption: 36 g/day). The variance in both inbred lines is approximately the same (3 g/day). During the first phase of selection for the high intake line, the researchers chose a group with mean intake of 103 g/day, and the resulting generation had a mean intake of 87 g/day. An F2 generation was also created by cross breeding the two inbred lines and allowing the resulting F1 to interbreed. Amongst the F2 only 0.10% showed a feed intake similar to the low line. In a QTL mapping experiment the F1 is backcrossed to the low intake parental line. In the offspring there is a bimodal phenotypic distribution with low (L) and intermediate (1) feed intake amongst individual rats. Markers A, B and Care on Chromosome 2, and markers D, E and Fare on Chromosome 6 (assume that the P1 generation was true breeding for all marker loci: ABCDEF and abcdef respectively). Wetenskaplikes gebruik hrotmodel om die genetiese oorsake van die ooreet te bestudeer in h kolonie laboratore wat lukrake teling ondergaan eet elke rot gemiddeld 60 g h dag met h variansie van 20 g/dag Twee ingeteelde lyne word geskep vanaf hierdie oorspronklike populasie (na vyf generasies van seleksie en inteling een met h hoe voerinname (gemiddelde verbruik 95 g/dag) en een met lae voeriname (gemiddelde verbruik: 36 g/dag). Die variansie in beide ingeteelde lyne is ongeveer dieselfde (3 g/dag) Gedurende die eerste fase van seleksie vir die hoë voerlyn, het die wetenskaplikes muise gekies met ʼn gemiddelde verbruik van 103 g/dag en die volgende nageslag het h gemiddelde verbruik van 87 g/dag gehad, h F2 generasie is ook gevorm deur die kruisteling van die twee ingeteelde lyne en deur toe te laat dat die F1 rotte met mekaar teel. Van hierdie F2 rotte het slegs 0.10% h verbruik soortgelyk aan die lae-voerlyn getoon In h KEL karteringseksperiment word die F1 teruggekruis na die lae voedsel inname ouerlike lyn in die nageslag is door h bimodale fenotipiese verspreiding met loe (L) en intermedière (0 inname onder individuele rotte Merkers A, B en C is op chromosoom 2, en meriers D E en Fis op chromescom 6 (aanvaar dat die P1 generasie suwertelend was vir alle merker loki ABCDEF en abcdef onderskeide Chromosome 6 Chromosome 2 Chromosoom 6 Chromosoom 2 Marker GenotypePhenotype Count Marker GenotypePhenotype Count Merker Genotipe Fenotipe Telling Merker Genotipe Fenotipe Telling DEF L 264 ABC L 423 DEF L 269 ABC L def I 257 abc 1 442 def 234 abc 1 439 DeF 232 AbC L 98 Def 254 Abc L 95 244 aBC 1 96 244 abc 1 95 103 AbC T 89 112 Abc 89 aBC 85 aBc 84 ABC 33 ABC 32 abc 32 abc 29 dEF def DeF Def DEF def DEF DE def def 1 L L 1 1 1 I L L 1 1 L L 29281 64 68 65 62 63 62 L L L 1 1 L L
Map the location of these gene(s) onto the appropriate chromosome(s), by giving the genetic distance between marker loci and potential QTL(s). Where there is independent assortment between marker and QTL, give the genetic distance as 50 CM. (round to the nearest whole number) Karteer die ligging van hierdie geen(e) op die toepaslike chromosoom(e), deur die genetiese afstande tussen merker loki en potensiele KEL(S) te gee. Waar daar onafhanklike sortering is tussen merker en KEL, gee die genetiese afstand as 50 CM. rond tot die naaste heelgetal)
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