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Explain the usage, reactivity and selectivity of lithium
diisopropylamide in this reaction.
Posted: Thu Jun 09, 2022 9:13 am
by answerhappygod
- Explain The Usage Reactivity And Selectivity Of Lithium Diisopropylamide In This Reaction 1 (89.95 KiB) Viewed 36 times
The Reaction 5.0 mmol 0.75 mL 1.0 equiv. isophorone Li 2.0 M solution 2.75 mL, 5.5 mmol 1.1 equiv. lithium diisopropylamide THF -78 °C [INT] methyl acrylate OMe 10.0 mmol 0.91 mL 2.0 equiv. THF -78 °C then warmed to RT quench with 1M HCI workup with ether/water/brine OMe a bicyclo[2.2.2]octane