1 Gemtuzumab And Trastuzumab Emtansine Are Two Examples Of Mab Drug Conjugates Adcs Where The Thiol Containing Drugs 1 (84.41 KiB) Viewed 74 times
1. Gemtuzumab and Trastuzumab emtansine are two examples of mAb-drug conjugates (ADCs) where the thiol-containing drugs calicheamicin and DM1, respectively, are attached to the mAb's via the linkers shown below. SO3 Nat SH H2N Fort ya Thiolhydrazide in Gemtuzumab Sulfo-SMCC in Trastuzumab emtansine (i) Show the chemistry involved in conjugating the drug (Calicheamicin-SH) to the antibody in Gemtuzumab and draw the target mAb-drug conjugate with a detailed linker region. (20) (ii) Show the chemistry involved in conjugating the drug (DM1-SH) to the antibody in Trastuzumab and draw the target mAb-drug conjugate with a detailed linker region. (20)
1. Gemtuzumab and Trastuzumab emtansine are two examples of mAb-drug conjugates (ADCs) where the thiol-containing drugs calicheamicin and DM1, respectively, are attached to the mAb's via the linkers shown below. S03 Nat SH -N whyx" for HAN 0 Thiolhydrazide in Gemtuzumab Sulfo-SMCC in Trastuzumab emtansine (1) Show the chemistry involved in conjugating the drug (Calicheamicin-SH) to the antibody in Gemtuzumab and draw the target mAb-drug conjugate with a detailed linker region. (20)
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