1. Onabotulinumtoxin A is a compound that weights 150,804
grams/mol, has thousands of hydrogen bonds (donors and acceptors),
and thus does not adhere to Lipinski’s Rule of 5, however, is a
widely used drug to treat various conditions like chronic
migraines, spasms of the muscles of the neck, and urinary
incontinence. Look up and state how Onabotulinumtoxin A is
administered and one of its commercial names.
2. Explain in 2-3 sentences how the pharmaceutical from Question
1 can be a successful drug candidate and is widely used, but does
not fit the Rule of 5.
1. Onabotulinumtoxin A is a compound that weights 150,804 grams/mol, has thousands of hydrogen bonds (donors and accepto
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