I "O O: Me Me "OH SMe 'N H NH SO₂Ph O b (-)-20 (+)-27. R=SO₂Ph (+)-gliocladin B (1), R=H 88% Scheme 3. Second-generation

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I O O Me Me Oh Sme N H Nh So Ph O B 20 27 R So Ph Gliocladin B 1 R H 88 Scheme 3 Second Generation 1 (31.66 KiB) Viewed 24 times

I "O O: Me Me "OH SMe 'N H NH SO₂Ph O b (-)-20 (+)-27. R=SO₂Ph (+)-gliocladin B (1), R=H 88% Scheme 3. Second-generation total synthesis of (+)-gliocladin B (1). Reagents and conditions: (a) MeSNa, TFA-MeNO₂ (1:1 v/v), 0-23 °C (77%) ; (b) hv (350 nm), 1,4- dimethoxynaphthalene, ascorbic acid, sodium ascorbate, H₂O, MeCN, 25 °C (88%). "N MeS 77% N. N 15