Question 1: A bit of organic chemistry (12+ 6 + 12 + 10 = 40 marks) a) Name the following compounds and state if they ar

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Question 1 A Bit Of Organic Chemistry 12 6 12 10 40 Marks A Name The Following Compounds And State If They Ar 1 (72.19 KiB) Viewed 76 times

Question 1: A bit of organic chemistry (12+ 6 + 12 + 10 = 40 marks) a) Name the following compounds and state if they are acidic, basic or neutral: i) ii) OH OH H3C H3C CH3 CH, iv) v) vi) HC CH NH2 H3C CH3 H3C NH2 b) Most patients with cancer pain respond to the administration of strong analgesic drugs such as morphine and its derivatives. Fentanyl (structure below) is one such drug. cray CH3 Redraw the fentanyl structure in your exam booklet and indicate the following: i) aromatic regions of the molecule, ii) chiral carbon atoms (if any), acidic and/or basic functional groups. 1 c) The pKa of fentanyl is 8.4. What is the pH of a 20 mL fentanyl injection solution containing 10 ug mL fentanyl (MW = 336.5g mol)? Is fentanyl likely to be fully soluble at this concentration and pH? Explain your answer. d) The degradation of fentanyl in the injection solution mentioned above follows first order kinetics with a rate constant of 0.0003 01. Assuming that the solution must be discarded by the pharmacy when the concentration of the fentanyl falls to less than 90% of its original, what is the shelf life of fentanyl injection solution? Question 2: Some thermodynamics (10 + 10 + 10 = 30 marks)