b) Table 2. Contraction in mm of smooth muscle by an agonist in thepresenceof increasingconcentrationsof anantagonist. A

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: B Table 2 Contraction In Mm Of Smooth Muscle By An Agonist In Thepresenceof Increasingconcentrationsof Anantagonist A 1 (137.89 KiB) Viewed 15 times

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b) Table 2. Contraction in mm of smooth muscle by an agonist in thepresenceof increasingconcentrationsof anantagonist. AntagonistBconcentration = = Agonistcon centration =0 = 1x10-10M = 1x10°M = 1x10M = 1x10 PM 0 0 0 1 0 2 4 9 17 24 29 30 30 30 WOO 1x10M 3x10M 1x10°M 3x10'M 1x10M 3x10M 1x10 M 3x10'M 1x10M 3x10 M 1x10M 3x10 M 1x10 M 3x10 M 1x10M OOOOOO 2 4 10 18 25 28 29 30 30 30 30 30 30 3 6 14 22 27 29 29 30 30 30 30 0 0 1 1 2 7 15 22 27 29 29 30 30 30 30 1 1 2 7 15 22 27 28 29 30 30 30 i) Plotaconcentration- responsecurvethatshowstherelationshipbetweenagonistconcentratio nand%maximumeffectatEACHoftheconcentrations of antagonist B shown in Table 2 (plot all the data onone graph). ii) Calculatethe EC50withoutantagonistandwithEACHoftheconcentration sofantagonistused. CalculatetheDoseRatioforEACHoftheantagonistc oncentrations. Writedownyouranswersandshowyourworkings.