A transcription regulatory protein contains both a nuclear localization and a nuclear export signal and is normally foun

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A transcription regulatory protein contains both a nuclear localization and a nuclear export signal and is normally found both in the nucleus and in the cytosol at comparable concentrations. This protein has a high-affinity binding partner in the nucleus. Upon activation of a certain signaling pathway, the binding protein in the nucleus is ubiquitylated and degraded. As a result of this, which of the following would you expect to see?
The transcription regulatory protein accumulates more in the nucleus.
The transcription regulatory protein accumulates more in the cytosol.
The distribution of the transcription regulatory protein does not change, but the expression of its target genes may be altered.
The distribution of the transcription regulatory protein does not change, and the expression of its target genes is not changed.