Please help me fill in the blanks, thanks. a. Down syndrome is the phenotype in humans caused by chromosome 21 _________

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Please help me fill in the blanks, thanks.
a. Down syndrome is the phenotype in humans
caused by chromosome 21 __________
b. Cells with complete sets of chromosome are
________. If one or more chromosomes is missing from a
set, or if extra chromosomes are present, the cells or organisms
are ________.
c. In ________, an otherwise diploid
cell is missing one chromosome. In ________, an extra
chromosome is present in addition to the two complete sets.
d. Females who are XO have ________
syndrome ; the phenotype includes unusually short stature and
sterility due to lower than normal doses of X-linked genes. Males
with more than one X chromosome (typically XXY) have
________syndrome; the phenotype includes
unusually tall stature and sterility due to abnormally high
X-linked gene dosages
e. Regions of chromosomes in two different
species where the genes and gene order are conserved are called
________.
f. ________________is a chromosomal
rearrangement where parts of two nonhomologous chromosomes switch
places
g. An inversion is ________if the
inverted region includes the centromere, and ________if
the inverted region does not include the centromere.
h. The failure of homologs to separate during
meiosis I, or the failure of sister chromatids to separate during
meiosis II, resulting in aneuploid meiotic products is called
________________
i. A _______ _ gene encodes a product
that impedes cell cycle progression or that protects the genome
from alterations. Loss-of-function mutations in these genes promote
cancer.
j. ________describes the tendency of
cancer cells to accumulate genomic changes at a rapid rate.
These changes can include increased frequencies of point mutations,
chromosomal rearrangements, aneuploidy, and even polyploidy.
k. ________mutations are mutations
found in the genomes of the cancerous cells in the patient that are
most likely to contribute to tumor formation. Other mutations
in the genomes of cancer cells that are unlikely to contribute to
tumor formation are often called ________ mutations.
l. A gain-of-function mutation in a
________can convert it to an________which
promotes cell cycle progression.
m. Cancer cells often express
________to counteract replicative ________.