Docking and Membrane Fusion. Q-8a. Choose from the terms below to Fill-in the Blanks. [All terms are used. Some terms ar

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Docking And Membrane Fusion Q 8a Choose From The Terms Below To Fill In The Blanks All Terms Are Used Some Terms Ar 1 (137.64 KiB) Viewed 16 times

Docking and Membrane Fusion. Q-8a. Choose from the terms below to Fill-in the Blanks. [All terms are used. Some terms are used more than once] Rab, SNARE, V- SNARE, t-SNARE, Tethering a. Identification of a vesicle to be docked depends on a diverse family of monomeric GTPases called proteins. First, a filamentous protein on a target membrane binds to a protein on the surface of a vesicle. This interaction allows the vesicle to dock on its particular target membrane. A on the vesicle then binds to a complementary on the target membrane. Whereas and proteins provide the initial recognition between a vesicle and its target membrane, complementary proteins ensure that transport vesicles dock at their appropriate target membranes. Together, the proteins catalyze the final fusion of the two membranes by squeezing out water making fusion more energetically favorable. b. What does the acronym SNARE stand for? c. Membrane fusion the rate limiting step of vesicular transport. Why? (What makes it so energetically unfavorable? How is this energy hurdle overcome? What happens at a molecular level when the fusion finally occurs?)