• You have taken up a position in a contract research laboratory which specialises in developing therapies for amyloid l

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You Have Taken Up A Position In A Contract Research Laboratory Which Specialises In Developing Therapies For Amyloid L 1 (41.67 KiB) Viewed 11 times

• You have taken up a position in a contract research laboratory which specialises in developing therapies for amyloid lateral sclerosis (ALS). A candidate drug has shown promise in the prevention of accumulation of SOD1 aggregates in a neuronal cell line with the SOD1 mutation. You have been tasked with testing this drug in more relevant models of ALS. A) Describe the condition of ALS and its pathophysiology B) Describe the process of generation of induced pluripotent stem cells and list the pros and cons of iPŠ cell technology C) Before starting your pre-clinical efficacy testing you need to conducta toxicity assay to establish safe concentrations of your candidate drug on your cells. Describe how you would conduct this assay. D) Your supervisor has instructed you to create a biobank of these cells. Briefly, what are the ethical considerations of doing this?