- 10 8 7 5 4 5 4 Table 1 Contraction Of Smooth Muscle By Three Agonists Contractile Response Mm Log Agonist 9 1 (146.69 KiB) Viewed 16 times
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| -10 -8 -7 -5 -4.5 -4 Table 1. Contraction of smooth muscle by three agonists Contractile response (mm) Log(agonist] -9 -8.5 -7.5 -6.5 -6 -5.5 (M) agonist-1 0.2 1.84 9.8 14.8 18 19.6 19.4 20 agonist-2 0 0 0.2 1 2.6 4 7.6 8.8 9.6 agonist-3 0 0 0 2 5.2 10 14.8 ง 20 20 20 ooo 9.8 10 10 NO 0.2 18 19.6 20 a) Experiments were performed on the contraction of smooth muscle using increasing concentrations of three agonists and the responses are given in Table 1. The maximum response of the system was 20 mm contraction. Calculate the % maximum response of the system for each concentration of agonist and plot graphs showing the dependence of the response on log [agonist]. Compare the three agonists in terms of their maximal effect and their potency using pharmacological terms.