4 Answer The Following Questions Based On The Knowledge From Lectures And Provided Information A Sildenafil Viagra 1 (121.49 KiB) Viewed 7 times
4. Answer the following questions based on the knowledge from lectures and provided information. (a) Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Revatio) is used to improve the ability to exercise in adults with pulmonary arterial hypertension. One of the key step of Sildenafil synthesis is shown below. OE O OEto i) Amine OH OH ii) H20 washing to remove the HCl residue i) What's the structure of Amine reagent? Amine structure ii) Why does not carboxyl acid react with amine? iii) Draw the mechanism of the reaction.
(b) 1. SOCI2 OEt OH 2. NaN3, heat 3. EtOH draw the products after the first and second step i) after 1st step after 2rd step ii) why does not the reaction afford the amine as final product? Explain it by drawing the mechanism of final step
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