enolate ion, ether to alcohol, Nu:- substitution, Grignard
reaction, and elimination.
- Cancer Drugs A Tamoxifen Cancer Drug Synthesis Involves Eas Enolate Ion Ether To Alcohol Nu Substitution Grigna 1 (50.38 KiB) Viewed 13 times
Dimethyl This facilitated the removal of the methyl group and
replaced it with an H to form a hydroxyl group. Thus forming
compound (E) in a 96% yield. This is a key step as it has left a
chink in the armour of the molecule. This can then be used to build
up a characteristic part of the Tamoxifen molecule. (eg the
(diemthylamino)ethyl group can be added easily from here)
Identify the reaction type, structural features, and reactive
sites, e.g., alpha carbon, describe the mechanism using curved
arrows, and other concepts that are important in the reaction.
Other concepts may include resonance structures and stability,
formal charge, and configuration of reactants and products.
Meo HO Lithium Ethane Thidate in DME (D) (E Step 3.