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х 3. (10 pts) Several different mutated SERCA pump proteins are being characterized in the laboratory. Each protein is u
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х 3. (10 pts) Several different mutated SERCA pump proteins are being characterized in the laboratory. Each protein is u
х 3. (10 pts) Several different mutated SERCA pump proteins are being characterized in the laboratory. Each protein is unable to transport Cat because of a single defect in one of the domains. Read the descriptions of the characteristics of each variant protein and determine which domain is defective in each case. In each experiment, 1 nM (1 x 10'M) protein was used. The lowest amount of ADP or P that can be detected is 100 nM. Phosphorylated protein can be detected by using radioactive ATP. Choose your answers from: A domain N domain P domain S, T (transmembrane) domains Variant 1: No Ca? is transported, and no ADP can be detected, but the protein becomes labeled with phosphate if radioactive ATP is used. defective domain: Variant 2: ADP and P are produced by the protein, but no Ca’ is transported. defective domain: Variant 3: No Ca? is transported, ATP does not bind to the protein, and no phosphorylated protein can be detected defective domain: Variant 4: No Ca? is transported, and ATP binds to the protein, but no phosphorylated protein can be detected defective domain:
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