Which of the following are TRUE, when describing the interaction of Oxygen, Blood and Haemoglobin? Select All that are t

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Which Of The Following Are True When Describing The Interaction Of Oxygen Blood And Haemoglobin Select All That Are T 1 (67.79 KiB) Viewed 52 times

Which of the following are TRUE, when describing the interaction of Oxygen, Blood and Haemoglobin? Select All that are true Oxygen is highly soluble in plasma, and the majority of Oxygen is transported in solution dissolved in Plasma When describing Haemoglobin-Oxygen equilibrium, the term "P50" indicates the Partial Pressure of Oxygen at which 50% of haemoglobin Oxygen binding sites are occupied Interactions between Haemoglobin subunits generally decrease Haemoglobin- Oxygen affinity, giving the single protein Myoglobin a higher affinity for Oxygen over a wide range of PO2 The smaller increase in PO2 required to increase Haemoglobin saturation (from 25% to 50%, and again from 50% to 75% saturation), indicates an increase in haemoglobin affinity for Oxygen, after one binding site is occupied. High PCO2, acidity and/or temperature decreases the affinity of Haemoglobin for Oxygen, and increases Oxygen unloading As one Haemoglobin subunit binds 02, it and the other subunits adopt the Relaxed conformation & become more likely to bind another 02. This Increased affinity promotes Oxygen "loading“ where PO2 is high. The larger increase in PO2 required to fully saturate Haemoglobin (from 75% to 100%), indicates a decrease in haemoglobin affinity for Oxygen compared to haemoglobin that is partially saturated. As one Haemoglobin subunit releases O2, it and the other subunits adopt the Tense conformation & become less likely to bind another 02. This decreased affinity promotes Oxygen "unloading" where PO2 is low. High PCO2, acidity and/or temperature increases the affinity of Haemoglobin for Oxygen, and increases Oxygen loading, When describing Haemoglobin-Oxygen equilibrium, the term "P50 indicates the proportion of possible Haemoglobin binding sites bound to oxygen, at a Partial Pressure of Oxygen of 50 mmHg.